An Animal Model of Chronic Cyclosporine Nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Mefenamic Acid induced nephrotoxicity: an animal model.
PURPOSE Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for the treatment of many joint disorders, inflammation and to control pain. Numerous reports have indicated that NSAIDs are capable of producing nephrotoxicity in human. Therefore, the objective of this study was to evaluate mefenamic acid, a NSAID nephrotoxicity in an animal model. METHODS Mice were dosed intraperitoneally with ...
متن کاملCyclosporine nephrotoxicity.
After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature anal...
متن کاملEffect of Erdosteine on Cyclosporine Induced Chronic Nephrotoxicity
Drugs and exogenous toxins, including aminoglyco-sides, amphotericin B, cisplatin, and radiocontrast media , may cause acute kidney injury (1). The manifestations which indicate that damage is occurring are a sudden increase in kidney injury biomarkers (NGAL [neutrophil gelatinase-associated lipocalin], KIM-1 [kidney injury molecule-1], etc.) and kidney failure (creatinine, cystatin C). This im...
متن کاملPolymerized type I collagen reduces chronic cyclosporine nephrotoxicity.
BACKGROUND Polymerized type I collagen (P-collagen) has been successfully used to reduce human hypertrophic scars due to its anti-fibrotic and anti-inflammatory properties. We therefore carried out a study to determine if P-collagen reduces functional and structural injury in chronic cyclosporine [cyclosporine A (CsA)] nephropathy. METHODS Four groups of six male Wistar rats fed with a low so...
متن کاملMineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity.
Recent studies from our laboratory have shown that the mineralocorticoid receptor (MR) blockade with spironolactone (Sp) prevented renal dysfunction and reduced renal injury in both acute and chronic cyclosporine (CsA) nephrotoxicity. This study was designed to evaluate whether Sp administration reduces functional and structural renal damage associated in the setting of preexisting chronic CsA ...
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ژورنال
عنوان ژورنال: Renal Failure
سال: 1999
ISSN: 0886-022X,1525-6049
DOI: 10.3109/08860229909085100